PD 0332991-d8 (Synonyms: Palbociclib-d8) |
| Catalog No.GC40092 |
Palbociclib D8 (PD 0332991 D8) est un Palbociclib marqué au deutérium. Le palbociclib est un inhibiteur sélectif et oral de CDK4 et CDK6 avec des CI50 de 11 et 16 nM, respectivement. Le palbociclib a le potentiel pour la recherche sur le cancer du sein ER-positif et HER2-négatif.
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Cas No.: 1628752-83-9
Sample solution is provided at 25 µL, 10mM.
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PD 0332991-d8 is intended for use as an internal standard for the quantification of PD 0332991 by GC- or LC-MS. PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclin D1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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