Pomalidomide-PEG3-azide |
| Catalog No.GC61618 |
Le pomalidomide-PEG3-azide est un conjugué ligand-lieur E3 ligase synthétisé qui incorpore le ligand céréblon À base de pomalidomide et le lieur PEG À 3 unités utilisé dans la technologie PROTAC.
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Cas No.: 2267306-15-8
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Fangqing Zhang, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.
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