Putrescine |
| Catalog No.GC19608 |
Putrescine (polyamines, spermidine and spermine) are organic cations of low molecular weight, it have important roles in cellular growth, cell differentiation, modulation of enzyme activities, regulation of ion channels and in the control of DNA and protein synthesis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 110-60-1
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Putrescine (polyamines, spermidine and spermine) are organic cations of low molecular weight, it have important roles in cellular growth, cell differentiation, modulation of enzyme activities, regulation of ion channels and in the control of DNA and protein synthesis[1-2].
Putrescine(100 ng/ml) promoted induction of immature bone marrow derived DCs (BMDCs), along with the increased phagocytosis and migration, and altered cytokine secretion in immature BMDCs [3]. Putrescine(0.5mM) improved the mitochondrial function of both oocyte and CCs via antioxygenation and the regulation of glucose metabolism [4-5]. Putrescine(100 μM) shifts L-arginine-metabolism related-genes on BALB/c macrophages and affects infection by L. amazonensis[6].
Putrescine produces antidepressant-like effects. Putrescine (1-10 mg/kg, i.p) significantly reduced the immobility time both in the mouse forced swimming test (FST) and in the tail suspension test (TST), two models predictive of antidepressant activity [7]. Putrescine(100 μM;24h) elicits ROS-dependent activation of the salicylic acid pathway in Arabidopsis thaliana[8].
References:
[1]. Park MH, Igarashi K. Polyamines and their metabolites as diagnostic markers of human diseases. Biomol Ther (Seoul). 2013 Jan;21(1):1-9. doi: 10.4062/biomolther.2012.097. PMID: 24009852; PMCID: PMC3762300.
[2]. Bird J, Mohd-Hidir S,et,al. Putrescine--a potent endogenous anti-inflammatory substance in inflammatory exudates. Agents Actions. 1983 Jun;13(4):342-7. doi: 10.1007/BF01971486. PMID: 6613748.
[3]. Huang P, Wang M, et,al. Putrescine accelerates the differentiation of bone marrow derived dendritic cells via inhibiting phosphorylation of STAT3 at Tyr705. Int Immunopharmacol. 2023 Mar;116:109739. doi: 10.1016/j.intimp.2023.109739. Epub 2023 Jan 26. PMID: 36706590.
[4]. Xu W, Li L, et,al. Putrescine delays postovulatory aging of mouse oocytes by upregulating PDK4 expression and improving mitochondrial activity. Aging (Albany NY). 2018 Dec 16;10(12):4093-4106. doi: 10.18632/aging.101699. PMID: 30554191; PMCID: PMC6326651.
[5]. Tao Y, Tartia A, et,al. Can peri-ovulatory putrescine supplementation improve egg quality in older infertile women? J Assist Reprod Genet. 2019 Mar;36(3):395-402. doi: 10.1007/s10815-018-1327-x. Epub 2018 Nov 22. PMID: 30467617; PMCID: PMC6439130.
[6]. Zanatta JM, Acuña SM, et,al. Putrescine supplementation shifts macrophage L-arginine metabolism related-genes reducing Leishmania amazonensis infection. PLoS One. 2023 Mar 31;18(3):e0283696. doi: 10.1371/journal.pone.0283696. PMID: 37000792; PMCID: PMC10065296.
[7]. Zomkowski AD, Santos AR, et,al. Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1419-25. doi: 10.1016/j.pnpbp.2006.05.016. Epub 2006 Jul 5. PMID: 16822602.
[8]. Liu C, Atanasov KE, et,al. Putrescine elicits ROS-dependent activation of the salicylic acid pathway in Arabidopsis thaliana. Plant Cell Environ. 2020 Nov;43(11):2755-2768. doi: 10.1111/pce.13874. Epub 2020 Sep 14. PMID: 32839979.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *