Robotnikinin |
| Catalog No.GC18475 |
La robotnikinine est une petite molécule capable de se lier À et d'inhiber l'activité de Sonic Hedgehog (Shh) signalant en amont de Smo .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1132653-79-2
Sample solution is provided at 25 µL, 10mM.
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Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development. Shh binds to its receptor, Patched (Ptch1), resulting in the de-repression of Smoothened. This leads to the activation of Gli2, which regulates the transcription of target genes that include Gli1 and Ptch1. Robotnikinin is the first identified small molecule inhibitor of Shh signaling that acts upstream of Smo, binding directly to Shh with a Kd value of 3.1 μM. Robotnikinin represses Gli-mediated transcription in primary human keratinocytes and synthetic human skin in a concentration-dependent manner.
Review for Robotnikinin
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
Review for Robotnikinin
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