TASP 0433864 |
Catalog No.GC50150 |
TASP 0433864 est un modulateur allostérique positif sélectif (PAM) du récepteur métabotropique du glutamate 2 (mGlu2) avec des valeurs EC50 de 199 nM et 206 nM contre les récepteurs mGlu2 humains et de rat, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1431980-60-7
Sample solution is provided at 25 µL, 10mM.
Selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.
Hiyoshi et al (2014) Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J.Pharmacol.Exp.Ther. 351 642 PMID:25277141
Average Rating: 5
(Based on Reviews and 15 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *