TAT TFA |
Catalog No.GC38854 |
TAT TFA (YGRKKRRQRRR) est dérivé du transactivateur de la transcription (TAT) du virus de l'immunodéficience humaine (VIH-1) et est un peptide pénétrant dans les cellules.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
TAT TFA (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins[1].
TAT (YGRKKRRQRRR) represents amino acids 47-57 of the human immunodeficiency virus type I (HIV-1) TAT protein. The positively charged protein transduction domain of the HIV-1 TAT protein (TAT-PTD; residues 47-57 of TAT) rapidly translocates across the plasma membrane of living cells. TAT (YGRKKRRQRRR; TAT-PTD) can cross the hydrophobic lipid bilayer of a cell membrane simply by passive diffusion[1].
[1]. Ziegler A, et al. Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters. Biophys J. 2004 Jan;86(1 Pt 1):254-63.
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