YF-2 |
| Catalog No.GC31099 |
YF-2 est un activateur d'histone acétyltransférase hautement sélectif et perméable À la barrière hémato-encéphalique, acétylates H3 dans l'hippocampe, avec des CE50 de 2,75 μM, 29,04 μM et 49,31 μM pour CBP, PCAF et GCN5, respectivement, ne montre aucun effet sur HDAC .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1311423-89-8
Sample solution is provided at 25 µL, 10mM.
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YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].
YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].
YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].
[1]. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.
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