RMM 46 |
Catalog No.GC50294 |
RMM 46 est un inhibiteur covalent sélectif et réversible des kinases de la famille MSK/RSK.
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Cas No.: 1307896-46-3
Sample solution is provided at 25 µL, 10mM.
MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.
Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298 PMID:23540679
Average Rating: 5
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