RR6 |
| Catalog No.GC32740 |
RR6 est un inhibiteur puissant, sélectif, réversible, compétitif et actif par voie orale de la vanine avec une IC50 de 540 nM pour la vanine-1 recombinante. RR6 inhibe également puissamment la pantéthéinase du sérum humain, bovin et rat avec des valeurs d'IC50 respectives de 40 nM, 41 nM et 87 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1351758-37-6
Sample solution is provided at 25 µL, 10mM.
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RR6 is a selective, reversible, and competitive vanin inhibitor.target: vaninIn vivo: Oral administration of RR6 in rats completely inhibited plasma vanin activity and caused alterations of plasma lipid concentrations upon fasting, thereby illustrating its potential use in chemical biology research. RR6 at 3 mg/mL inrats caused a nearly complete inhibition of plasma vanin.
[1]. Jansen PA et al. Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease. ACS Chem Biol. 2013 Mar 15;8(3):530-4.
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