(S)-FTY720-phosphonate |
| Catalog No.GC71271 |
(S)-FTY720-phosphonate est un agoniste du récepteur S1P 1 (S1PR1), utilisé dans la recherche de maladies inflammatoires aiguës telles que les lésions pulmonaires aiguës.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1142015-10-8
Sample solution is provided at 25 µL, 10mM.
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FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1[1].
FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].
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