SARI-59-801 (Synonyms: Sari 59-801; Sari-59-801; Sari59-801; Sari 59801; Sari-59801; Sari59801; Sandoz 59-801; Sandoz59-801; Sandoz-59-801;) |
Catalog No.GB62218 |
Sari 59-801 is a novel, orally effective hypoglycemic compound which appears to act largely, if not entirely, by stimulation of insulin release.
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Cas No.: 80565-58-8
Sample solution is provided at 25 µL, 10mM.
Sari 59-801 is a novel, orally effective hypoglycemic compound which appears to act largely, if not entirely, by stimulation of insulin release. The 2-hr hypoglycemic ED25 in fasting mice was 110 mg/kg; the plasma insulin levels were increased, with an ED50 of 47 mg/kg. Significant hypoglycemic activity was observed 2 hr after oral administration of 59-801 to fasting rats (ED25 = 86 mg/kg), while plasma insulin was elevated by 62% at 100 mg/kg. SARI-59-801 was more potent in producing hypoglycemia (ED25 = 47 mg/kg) than their lean littermates (ED25 = 131 mg/kg).
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