Setipiprant (Synonyms: ACT-129968) |
| Catalog No.GC19327 |
Setipiprant (ACT-129968) est un antagoniste de CRTH2 actif et sélectif par voie orale.
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Cas No.: 866460-33-5
Sample solution is provided at 25 µL, 10mM.
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Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.IC50 value: 6.0 nMTarget: PGD2in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist. CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells. Thus, antagonism of CRTH2 receptors is considered to be a promising therapeutic target for various allergic diseases and asthma.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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