SJB3-019A |
| Catalog No.GC13401 |
SJB3-019A est un puissant et nouvel inhibiteur de l'USP1, 5 fois plus puissant que SJB2-043 pour favoriser la dégradation et la cytotoxicité de l'ID1 dans les cellules K562 avec une IC50 de 0,0781 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2070015-29-9
Sample solution is provided at 25 µL, 10mM.
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SJB3-019A is a potent and novel inhibitor of USP1 with IC50 value of 0.0781 μM [1].
Ubiquitin-specific protease 1 (USP1) is a deubiquitinating (DUB) enzyme and removes polyubiquitin chains from the DNA binding 1 (ID1) protein, which plays an important role in the proliferation and progression of cancers, such as leukemia [1].
SJB3-019A is a potent and novel USP1 inhibitor. In K562 cells, SJB3-019A exhibited 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity. In HeLa cells, SJB3-019A increased the levels of Ub-PCNA and Ub-FANCD2 and reduced the homologous recombination activity [1].
Reference:
[1]. Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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