SKA-111 |
| Catalog No.GC70205 |
SKA-111 est un activateur sélectif de potassium phannel KCa 3.1, évoque l’hyperpolarisation de la membrane KCa 3.1 dans la cellule endothéliale porcine.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1369170-24-0
Sample solution is provided at 25 µL, 10mM.
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SKA-111 (1 μM, 5 min) evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) [1].
SKA-111 (1 μM for cardiac perfusion) improves Bradykinin -induced coronary dilations in the isolated rat heart[1].
References:
[1]. Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92.
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