Sodium gualenate (Guaiazulenesulfonate sodium) |
| Catalog No.GC31775 |
Le gualénate de sodium (Guaiazulenesulfonate de sodium) (Guaiazulenesulfonate de sodium) est un dérivé hydrophile du guaiazulene avec d'excellents effets anti-inflammatoires et cicatrisants principalement utilisé pour le traitement de l'ulcère duodénal, de l'ulcère gastrique et de la gastrite.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6223-35-4
Sample solution is provided at 25 µL, 10mM.
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Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.
Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at room temperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was found that a kneaded mixture of Sodium gualenate and cornstarch (weight ratio; 1:250) for tableting with water is stable. So, during production, Sodium gualenate could be stabilized using water[1]. Sodium gualenate slightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyte emigration induced by fMLP[2].
Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions in vivo have also been shown[2].
[1]. Nakamichi K, et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur J Pharm Biopharm. 2003 Nov;56(3):347-54. [2]. Cao T, et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent. Chem Biol Drug Des. 2016 Aug;88(2):264-71.
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