TAT-Gap19 |
| Catalog No.GC50390 |
TAT-Gap19, un peptide mimétique Cx, est un inhibiteur spécifique de l'hémicanal de la connexine43 (Cx43 HC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1507930-54-2
Sample solution is provided at 25 µL, 10mM.
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Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 . Active in vivo. Brain penetrant.
Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID:25374505 |Freitas-Andrade and Naus (2016) Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 323 207 PMID:25913636
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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