Tat-QFNP12 (trifluoroacetate salt) |
| Catalog No.GC91026 |
Un inhibiteur peptidique de l'interaction protéine-protéine NDRG2-PPM1A
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Tat-QFNP12 is a peptide containing a transcriptional transactivator (Tat) transmembrane domain and an inhibitor of the protein-protein interaction between N-Myc downstream regulated gene 2 (NDRG2) and the protein phosphatase Mg2+/Mn2+ dependent 1A (PPM1A).1 It decreases the loss of blood-brain barrier endothelial tight junctions induced by increased levels of matrix metalloproteinase-9 (MMP-9), reduces cerebral edema, as well as increases spontaneous activity and symmetry of limb movement, in an endovascular puncture-induced mouse model of subarachnoid hemorrhage when administered at a dose of 20 mg/kg.
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