TBTA (Synonyms: Tris(benzyltriazolylmethyl)amine) |
Catalog No.GC45003 |
Le TBTA (TBTA) est un ligand qui agit comme un outil biochimique pour le marquage des protéines et des enzymes.
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Cas No.: 510758-28-8
Sample solution is provided at 25 µL, 10mM.
TBTA (tris(benzyltriazolylmethyl)amine) is a tertiary amine containing a 1,2,3-triazole group[1]. TBTA complexes with copper(I) and promotes click reaction catalysis by stabilizing the copper(I) oxidation state[2]. TBTA is one of the most widely used water-insoluble ligands in copper-catalyzed azide-alkyne cycloaddition (CuAAC)[3].
Click chemistry is a versatile reaction that can be used for the synthesis of a variety of conjugates. Virtually any biomolecule can be easily labelled with small molecules, such as fluorescent dyes, biotin, etc using click chemistry method.
Click chemistry reaction takes place between two components: azide and alkyne (terminal acetylene). Both azido and alkyne groups are nearly never encountered in natural biomolecules. Hence, the reaction is highly bioorthogonal and specific.
References:
[1] Alireza Movahedi, et al. One-pot synthesis of TBTA-functionalized coordinating polymers. Reactive and Functional Polymers.2014. 82:1-8.
[2] Kennedy D C, McKay C S, Legault M C B, et al. Cellular consequences of copper complexes used to catalyze bioorthogonal click reactions[J]. Journal of the American Chemical Society, 2011, 133(44): 17993-18001.
[3] Hagmann V, Sommer S, Fabian P, et al. Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery[J]. Scientific Reports, 2018, 8(1): 16014.
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