TC-G 1005 |
| Catalog No.GC50107 |
TC-G 1005 est un agoniste puissant, sélectif et actif par voie orale du récepteur 5 couplé aux protéines Takeda G (TGR5), avec des CE50 de 0,72 et 6,2 nM pour hTGR5 et mTGR5, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1415407-60-1
Sample solution is provided at 25 µL, 10mM.
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Potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
Duan et al (2012) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 55 10475 PMID:23148522
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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