TD-106 |
| Catalog No.GC33068 |
TD-106 est un modulateur de cereblon (CRBN), qui peut être utilisé pour la dégradation ciblée des protéines. Les PROTAC BRD4 avec TD-106 induisent la dégradation de BRD4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2250288-69-6
Sample solution is provided at 25 µL, 10mM.
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TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation[1].
TD-106 (0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM, 10 μM, and 100 μM; 72?hours) inhibits the proliferation of NCI-H929 myeloma cell line with an CC50?of?0.039?μM[1].TD-106 (1, 10, 100, and 1000 nM) induces the degradation of IKZF1/3 in NCI-H929?cells[1].|| Cell Cytotoxicity Assay[1]||Cell Line:|NCI-H929?cells|Concentration:|72?hours|Incubation Time:|0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM, 10 μM, and 100 μM|Result:|Inhibited cell proliferation with an CC50?of?0.039?μM.
TD-106 (50 mg/kg; intraperitoneally; q.d. for 14 days) possesses anti-myeloma activity in SCID mice with TMD-8 xenograft model.|| Animal Model:|Female SCID (CB-17/IcrCri-scid) mice with TMD-8 xenograft model[1]|Dosage:|50 mg/kg|Administration:|Intraperitoneally (i.p.); q.d. for 14 days|Result:|Treatment inhibited tumor growth during this duration.
[1]. Kim SA, et al. A novel cereblon modulator for targeted protein degradation. Eur J Med Chem. 2019 Mar 15;166:65-74.
| Cas No. | 2250288-69-6 | SDF | |
| Canonical SMILES | NC1=CC=CC(N=NN2C3CCC(NC3=O)=O)=C1C2=O | ||
| Formula | C12H11N5O3 | M.Wt | 273.25 |
| Solubility | DMSO : ≥ 125 mg/mL (457.46 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6597 mL | 18.2983 mL | 36.5965 mL |
| 5 mM | 0.7319 mL | 3.6597 mL | 7.3193 mL |
| 10 mM | 0.366 mL | 1.8298 mL | 3.6597 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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