TLR7/8 antagonist 2 |
| Catalog No.GC70900 |
TLR7/8 antagonist 2 (composé 15) est un puissant agoniste actif par voie orale du tlr7 / 8 avec des CI50 de 4,9 et 0,6 nm, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2769085-03-0
Sample solution is provided at 25 µL, 10mM.
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TLR7/8 antagonist 2 (Compound 15) is a potent and orally active agonist of TLR7/8 with IC50s of 4.9 and 0.6 nM, respectively. Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as lupus erythematosus. TLR7/8 antagonist 2 has the potential for the research of autoimmune diseases.
References:
[1]. Claudia Betschart, et al. Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.
Review for TLR7/8 antagonist 2
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for TLR7/8 antagonist 2
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