β-Tocotrienol |
| Catalog No.GC11519 |
β-Le tocotriénol est une forme de vitamine E.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 490-23-3
Sample solution is provided at 25 µL, 10mM.
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β-Tocotrienol is an antioxidant.
There are four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) forms of vitamin E, which is known for its antioxidant activity. Tocotrienols are present in high concentrations in palm oil and wheat germ.
In vitro: The antioxidant activity of the tocopherols and tocotrienols was found to be mainly due to their ability to donate their phenolic hydrogens to lipid free-radicals. Although it is generally agreed that the relative antioxidant activity of the tocopherols was in the order α>β>γ>δ [1].
In vivo: In a previous study, mice were fed a nonpurified control diet, an atherogenic diet alone or the atherogenic diet supplemented with α- and β-tocopherols. Results showed that compared with mice fed the control diet, plasma cholesterol was fourfold greater in mice fed the atherogenic diet. Mice fed the atherogenic diet had much higher VLDL, intermediate density lipoprotein (IDL) and LDL cholesterol and markedly lower HDL cholesterol than the controls. Moreover, in mice fed the atherogenic diet, the hepatic cholesterol plus cholesterol ester concentration was 4.4-fold greater than in mice fed the control diet. Mice fed the atherogenic diet had large atherosclerotic lesions at the level of the aortic valve. The 0.5 g/100 g alpha-tocopherol and palm carotenoid supplements had no effect [2].
Clinical trial: So far, no clinical study has been conducted.
References:
1. Kamal-Eldin, A., and Appelqvist, L.. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671-701 (1996).
2. Black, T.M.,Wang, O.,Maeda, N., et al. Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. Journal of Nutrition 130(10), 2420-2426 (2000).
| Cas No. | 490-23-3 | SDF | |
| Chemical Name | (2R)-3,4-dihydro-2,5,8-trimethyl-2-[4,8,12-trimethyl-3E,7E,11-tridecatrien-1-yl]-2H-1-benzopyran-6-ol | ||
| Canonical SMILES | C[C@]1(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)OC2=C(C)C=C(O)C(C)=C2CC1 | ||
| Formula | C28H42O2 | M.Wt | 410.6 |
| Solubility | ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide | Storage | -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4355 mL | 12.1773 mL | 24.3546 mL |
| 5 mM | 0.4871 mL | 2.4355 mL | 4.8709 mL |
| 10 mM | 0.2435 mL | 1.2177 mL | 2.4355 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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