UFP101 (trifluoroacetate salt) |
| Catalog No.GC90532 |
Un peptide synthétique et un antagoniste du récepteur de la nociceptine.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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UFP101 is a synthetic peptide and an antagonist of the nociceptin receptor (Ki = 0.06 nM in CHO cells expressing the human receptor).1 It is selective for the nociceptin receptor over the κ-opioid receptor (Ki = 204 nM in CHO cells expressing the rat receptor). UFP101 inhibits GTPγS release from the nociceptin receptor expressed in CHO cell membranes (EC50 = 1.86 nM). Intracerebroventricular administration of UFP101 (10 nmol/animal) increases the latency to tail withdrawal in the tail-flick test in mice. UFP101 (0.003, 0.03, and 0.3 mg/kg) increases survival in a mouse model of sepsis induced by cecal ligation and puncture.2
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