Ursodiol (Synonyms: NSC 683769, UDCA, Ursodiol) |
| Catalog No.GC13363 |
L'ursodiol (ursodésoxycholate) est un acide biliaire secondaire issu de la transformation de l'acide (chéno)désoxycholique par les bactéries intestinales, agissant comme un régulateur clé de l'intégrité de la barrière intestinale et essentiel au métabolisme des lipides.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 128-13-2
Sample solution is provided at 25 µL, 10mM.
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Ursodiol (Ursodeoxycholic acid) is bile acids used in treatment of primary biliary cirrhomized (PBC) [1].
Ursodiol (Ursodeoxycholic acid) has been reported to prevent progression of PBC, and increase survival. In addition, Ursodiol has been revealed to inhibit the initiation and postinitiation phases of azoxymethane-induced colonic tumor development. Moreover, Ursodiol has been noted to dose-dependently inhibit the viability of HepG2 and BEL7402 cell lines with IC50 values of 0.92mmol/L and 0.86mmol/L, respectively. Ursodiol has also reported to dose-dependently and significantly enhance the apoptosis rates in HepG2 and BEL7402 cells. Besides, treatment of Ursodiol has shown the reduction of the ecpression of cell cycle regulating proteins (cyclinD1,cyclin D3, Cdk2 and Cdk4) in Western blot analysis [1].
References:
[1] Liu H1, Qin CY, Han GQ, Xu HW, Meng M, Yang Z. Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines. World J Gastroenterol. 2007 Mar 21;13(11):1652-8.
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