WDR5-IN-4 TFA |
| Catalog No.GC61380 |
WDR5-IN-4 TFA est un inhibiteur du site WIN de la protéine 5 contenant des répétitions WD associée À la chromatine (WDR5), avec un Kd de 0,1 nM. WDR5-IN-4 TFA déplace WDR5 de la chromatine et diminue l'expression des gènes associés, provoquant une inhibition de la traduction, un stress nucléolaire. Activité anticancéreuse.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].
[1]. Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
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