WF-3681 (Synonyms: (±)-WF-3681) |
| Catalog No.GC48884 |
A fungal metabolite
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 105364-56-5
Sample solution is provided at 25 µL, 10mM.
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WF-3681 is a butenolide fungal metabolite that has been found in Acremonium.1 It inhibits aldose reductase (IC50 = 0.25 µM for the rabbit lens enzyme).2
1.Ghisalberti, E.L., Hargreaves, J.R., and McConville, E.Butenolides from a cultured microfungus, Acremonium spNat. Prod. Res.18(2)105-109(2004) 2.Nishikawa, M., Yoshida, K., Okamoto, M., et al.Studies on WE-3681, a novel aldose reductase inhibitor. III. Effects of WF-3681 and its derivatives on sorbitol accumulation in diabetic ratsJ. Antibiot. (Tokyo)43(9)1186-1188(1990)
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