Win-62005 |
| Catalog No.GC32659 |
Win-62005 est un inhibiteur de l'AMP cyclique phosphodiestérase III (PDE III) avec Kis de 25 et 26 nM pour le cœur de rat et l'aorte canine, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 152633-54-0
Sample solution is provided at 25 µL, 10mM.
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Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.
Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1].
After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1].
[1]. Dundore RL, et al. Species-dependent pharmacodynamic effects of the selective low Km cyclic AMP phosphodiesterase III inhibitors WIN 58993 and WIN 62005. J Cardiovasc Pharmacol. 1995 Jan;25(1):14-21.
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