XMD16-5 |
| Catalog No.GC19385 |
XMD16-5 est un puissant inhibiteur de TNK2 avec des valeurs IC50 de 16 et 77 nM pour les mutations D163E et R806Q, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1345098-78-3
Sample solution is provided at 25 µL, 10mM.
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XMD16-5 is a potent TNK2 inhibitor with IC50 values of 16 and 77 nM for the D163E and R806Q mutations, respectively.
XMD16-5 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD16-5 has IC50s of 16 nM and 77 nM for the D163E and R806Q mutations. The effects of XMD16-5 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD16-5[1].
References:
[1]. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.
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