XT2 |
| Catalog No.GC65586 |
XT2 est un inhibiteur puissant, actif par voie orale et sélectif de la kinase inductrice de NF-κB (NIK) avec une IC50 de 9,1 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2582816-37-1
Sample solution is provided at 25 µL, 10mM.
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XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases[1].
[1]. Li Z, et al. Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo. J Med Chem. 2020;63(8):4388-4407.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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