FSEN1 |
| Catalog No.GC90713 |
An inhibitor of FSP1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 862808-01-3
Sample solution is provided at 25 µL, 10mM.
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FSEN1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50 = 313 nM).1 It is selective for FSP1 over NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1; IC50 = >100 µM). FSEN1 induces cell death in GPX4-/- H460 non-small cell lung cancer (NSCLC) cells (EC50 = 69.36 nM) but not control H460 cells expressing Cas9 (H460Cas9). It sensitizes A549, Huh7, HCC1143, U2OS, SU-DHL-5, and T98G cancer cells to ferroptosis induced by (1S,3R)-RSL3 when used at concentrations ranging from 10 to 1,000 nM. FSEN1 also sensitizes H460Cas9 cells, but not FSP1-/- H460 cells, to cell death induced by the ferroptosis inhibitors didroartemisinin or FINO2 .
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