Galanin (rat, mouse) (trifluoroacetate salt) (Synonyms: GAL (rat, mouse)) |
| Catalog No.GC43724 |
Galanin is a neuropeptide with diverse biological activities.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). [1] Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol . [2] In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and mechanical stimulation in a rat model of carrageenin-induced inflammation when administered at a dose of 2 nmol injected into the nucleus accumbens.[3][4] Galanin (5 μg, i.c.v.) also inhibits acetylcholine release induced by scopolamine in the ventral hippocampus of freely moving rats. [5]
Reference:
[1]. Branchek, T.A., Smith, K.E., Gerald, C., et al. Galanin receptor subtypes. Trends Pharamacol. Sci. 21(3), 109-117 (2000).
[2]. Gu, Z.F., Pradhan, T.K., Coy, D.H., et al. Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: Identification of a novel galanin receptor subtype. J. Pharmacol. Exp. Ther. 272(1), 371-378 (1995).
[3]. Crawley, J.N., Austin, M.C., Fiske, S.M., et al. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. J. Neurosci. 10(11), 3695-3700 (1990).
[4]. Yang, Y., Zhang, Y., Li, X.H., et al. Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain. Neurosci. Res. 97, 20-25 (2015).
[5]. Taber, M.T., and Crawley, J.N. Galanin attenuates the effects of scopolamine but not exposure to a novel environment on acetylcholine release in the rat ventral hippocampus. Psychobiol. 27(1), 57-62 (1999).
| Cas No. | SDF | ||
| Synonyms | GAL (rat, mouse) | ||
| Chemical Name | glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-histidyl-L-alanyl-L-isoleucyl-L-α-aspartyl-L-asparaginyl-L-histidyl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-lysyl-L-histidylglycyl-L-leucyl-L-threoninamide, 2,2,2-trifluoroacetate | ||
| Canonical SMILES | NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC(CNC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@@H](NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC(CN[H])=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)=O)=O)C)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)C)=O)=O)CC(O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)CC7=CC=CC=C7)=O)=O)CC(O)=O)=O)=O)CC8=CN=CN8)=O)=O)=O)=O.OC(C(F)(F)F)=O | ||
| Formula | C141H211N43O41•XCF3COOH | M.Wt | 3164.4 |
| Solubility | 1mg/mL in water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.316 mL | 1.5801 mL | 3.1602 mL |
| 5 mM | 0.0632 mL | 0.316 mL | 0.632 mL |
| 10 mM | 0.0316 mL | 0.158 mL | 0.316 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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