Galantide |
| Catalog No.GC30931 |
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 138579-66-5
Sample solution is provided at 25 µL, 10mM.
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Galantide is a reversible and non-specific galanin receptor antagonist.
Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. The antagonist is also found to displace 125I-monoiodo-[TyrZ6]galanin from membranes of the insulin producing Rin m 5F cells with an IC50 value of less than 0.1 nM[1].
Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin[2]. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41-49%[3]. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM[4].
[1]. Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediatedinhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992 Jan 14;210(2):183-8. [2]. Benelli A, et al. Galantide stimulates sexual behaviour in male rats. Eur J Pharmacol. 1994 Aug 1;260(2-3):279-82. [3]. Barreto SG, et al. The efficacy of combining feG and galantide in mild caerulein-induced acutepancreatitis in mice. Peptides. 2010 Jun;31(6):1076-82. [4]. Arletti R, et al. Galantide improves social memory in rats. Pharmacol Res. 1997 Apr;35(4):317-9.
Animal experiment: | Rats: Galantide is dissolved in 0.9% NaCl. The i.c.v. injection is given to the resident rat immediately after removal of the juvenile, at the end of the first encounter. Control rats receive an equal volume (4 µL) of saline by the same route, at the same infusion rate (1 µL/20 s) and at the same time. A minimum of 10 adult rats are used for each dose level[4]. Mice: Galantide stock solution is prepared in 0.01% bovine serum albumin in saline. The mice are allocated to 7 groups: Mice administered the vehicle for injection (saline alone), mice administered only caerulein (AP alone), mice administered only galantide (GT alone) or feG (feG alone), mice administered caerulein and galantide (AP+GT) or caerulein and feG (AP+feG) and finally mice that are administered with caerulein, galantide and feG (AP+GT+feG). On the day prior to the AP induction, a blood sample is collected to measure the basal plasma amylase activity[3]. |
References: [1]. Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediatedinhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992 Jan 14;210(2):183-8. | |
| Cas No. | 138579-66-5 | SDF | |
| Canonical SMILES | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 | ||
| Formula | C104H151N25O26S | M.Wt | 2199.53 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.4546 mL | 2.2732 mL | 4.5464 mL |
| 5 mM | 0.0909 mL | 0.4546 mL | 0.9093 mL |
| 10 mM | 0.0455 mL | 0.2273 mL | 0.4546 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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