E3 ligase Ligand 16 (Synonyms: MDM2 ligand 1; E3 ligase Ligand 16) |
| Catalog No.GC35930 |
E3 ligase Ligand 16 (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTAC.
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Cas No.: 2249750-27-2
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 16 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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