Dextromethorphan (CRM) (Synonyms: DXM, DMethorphan) |
| Catalog No.GC45421 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 125-71-3
Sample solution is provided at 25 µL, 10mM.
Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.1 However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).1,2,3 DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.1,4
References
1. Weinbroum, A.A., Rudick, V., Paret, G., et al. The role of dextromethorphan in pain control. Can.J.Anesth. 47(6), 585-596 (2000).
2. Damaj, M.I., Flood, P., Ho, K.K., et al. Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: In vitro and in vivo selectivity. Journal of Pharmacology and Experimental Therapeutics 312(2), 780-785 (2005).
3. Netzer, R., Pflimlin, P., and Trube, G. Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons. European Journal of Pharmacology 238, 209-216 (1993).
4. Chen, Y.W., Chu, K.S., Lin, C.N., et al. Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats. Anesthesia and Analgesia 104(5), 1251-1255 (2007).
| Cas No. | 125-71-3 | SDF | |
| Synonyms | DXM, DMethorphan | ||
| Chemical Name | (9α,13α,14α)-3-methoxy-17-methyl-morphinan | ||
| Canonical SMILES | CN1[C@@H]2[C@@]3([H])CCCC[C@@]3(CC1)C4=CC(OC)=CC=C4C2 | ||
| Formula | C18H25NO | M.Wt | 271.4 |
| Solubility | A 1 mg/ml solution in methanol | Storage | Store at 2-8°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.6846 mL | 18.423 mL | 36.846 mL |
| 5 mM | 0.7369 mL | 3.6846 mL | 7.3692 mL |
| 10 mM | 0.3685 mL | 1.8423 mL | 3.6846 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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