GLP-2 (1-34) (human) (trifluoroacetate salt) (Synonyms: Glucagon-like Peptide 2 (1-34)) |
| Catalog No.GC45463 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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GLP-2 (1-34) (human) is a synthetic form of the human peptide GLP-2 that contains the full human sequence with the addition of an arginine residue at the C-terminal end.1 It increases survival of myenteric neurons cultured alone (EC50 = 0.35 nM) and when co-cultured with mast cells to induce cell death.2 It does not stimulate insulin release from isolated rat pancreatic islets in the presence of glucose when used at concentrations ranging from 2.5 to 250 nM.1 GLP-2 (1-34) (human) also does not affect formation of adenomas in a transgenic model of intestinal tumorigenesis using ApcMin/+ mice.3
References
1. Schmidt, W.E., Siegel, E.G., and Creutzfeldt, W. Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia 28(9), 704-707 (1985).
2. Voss, U., Sand, E., Hellstr•m, P.M., et al. Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons. BMC Gastroenterol. 12, 30 (2012).
3. Koehler, J.A., Harper, W., Barnard, M., et al. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. Cancer Res. 68(19), 7897-7904 (2008).
| Cas No. | SDF | ||
| Synonyms | Glucagon-like Peptide 2 (1-34) | ||
| Canonical SMILES | OCC1=C(O)C=CC(C(O)CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C1 | ||
| Formula | C171H266N48O56S.XCF3COOH | M.Wt | 3922.3 |
| Solubility | Water: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.255 mL | 1.2748 mL | 2.5495 mL |
| 5 mM | 0.051 mL | 0.255 mL | 0.5099 mL |
| 10 mM | 0.0255 mL | 0.1275 mL | 0.255 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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