Sematilide (hydrochloride) (Synonyms: CK-1752A) |
| Catalog No.GC45564 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 101526-62-9
Sample solution is provided at 25 µL, 10mM.
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Sematilide is a class III antiarrhythmic agent and an analog of sotalol .1 It prolongs electrically stimulated action potential duration (APD) and increases the effective refractory period (ERP) in isolated guinea pig left atria. Sematilide decreases spontaneous sinoatrial beating rates and induces ERP prolongation of the atrioventricular node in isolated perfused canine hearts.2 In situ, sematilide (1 mg/kg) increases ERP, prolonging cardiac refractoriness, in open-chest dog hearts. Sematilide (0.3-6 mg/kg) inhibits arrhythmias induced by programmed electrical stimulation (PES), but not coronary ligation and reperfusion, two-stage coronary ligation, adrenaline, or digitalis, in dogs.3 Formulations containing sematilide have been used in the treatment of arrhythmias.
References
1. Ishii, Y., Muraki, K., Kurihara, A., et al. Effects of sematilide, a novel class III antiarrhythmic agent, on action potential in guinea pig atrium. Jpn. J. Pharmacol. 68(2), 175-182 (1995).
2. Yamada, A., Motomura, S., and Hashimoto, K. Comparison of direct negative chronotropic and positive inotropic effects of sematilide to those of E-4031 and MS-551 and the reverse frequency-dependent prolongation of cardiac refractoriness of sematilide. J. Cardiovasc. Pharmacol. 27(1), 159-166 (1996).
3. Xue, Y.X., Eto, K., Akie, Y., et al. Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models. Jpn. J. Pharmacol. 70(2), 129-138 (1996).
| Cas No. | 101526-62-9 | SDF | |
| Synonyms | CK-1752A | ||
| Canonical SMILES | CS(NC1=CC=C(C(NCCN(CC)CC)=O)C=C1)(=O)=O.Cl | ||
| Formula | C14H23N3O3S.HCl | M.Wt | 349.9 |
| Solubility | DMF: 12 mg/ml,DMSO: 12 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 5 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.858 mL | 14.2898 mL | 28.5796 mL |
| 5 mM | 0.5716 mL | 2.858 mL | 5.7159 mL |
| 10 mM | 0.2858 mL | 1.429 mL | 2.858 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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