TFLLR-NH2 (trifluoroacetate salt) |
| Catalog No.GC45576 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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TFLLR-NH2 is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that induces calcium mobilization in isolated rat dorsal root ganglion neurons (EC50 = 1.9 μM).1 In vivo, TFLLR-NH2 (3 μmol/kg) stimulates plasma extravasation in the bladder, esophagus, stomach, intestine, and pancreas in wild-type, but not PAR1-/-, mice. It also reduces carrageenan-induced hyperalgesia in rats.2
References
1. de Garvilla, L., Vergnolle, N., Young, S.H., et al. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br. J. Pharmacol. 133(7), 975-987 (2001).
2. Kawabata, A., Kawao, N., Kuroda, R., et al. The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats. Peptides 23(6), 1181-1183 (2002).
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