4-(α-L-Rhamnosyloxy)benzyl isothiocyanate (Synonyms: Moringin) |
| Catalog No.GF27885 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 73255-40-0
Sample solution is provided at 25 µL, 10mM.
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In SH-SY5Y human neuroblastoma cells, Moringin (16.4 碌M; 24-72 h) significantly reduces SH-SY5Y cell growth in a time and concentration-dependent manner[2].
Moringin (1.64-8.2 渭M; 24 h) increases the expression of p53, p21, and Bax at both the protein and transcriptional level in SH-SY5Y cells. Moringin significantly increases the gene expression of both caspase 3 and 9 and enhanced their cleavage, thereby initiating an intrinsic apoptotic cascade[2].
Moringin inhibits nuclear translocation of NF-魏B[2].
In experimental autoimmune encephalomyelitis (EAE) mice, Moringin (10 mg/kg; intraperitoneally daily for 5 week) pretreatment normalizes the aberrant Wnt-尾-catenin pathway, resulting in GSK3尾 inhibition and 尾-catenin upregulation, which regulates T-cell activation (CD4 and FoxP3), suppresses the main inflammatory mediators (IL-1尾, IL-6, and COX2), through activation of PPAR纬. Moringin increases antioxidant Nrf2 expression in EAE mice[3].
[1]. Gigliola Borgonovo, et al. Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. Molecules. 2020 Feb 22;25(4):976.
[2]. Santa Cirmi, et al. Moringin from Moringa Oleifera Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-魏B and Apoptotic Related Factors. Int J Mol Sci. 2019 Apr 19;20(8):1930.
[3]. Sabrina Giacoppo, et al. Moringin activates Wnt canonical pathway by inhibiting GSK3尾 in a mouse model of experimental autoimmune encephalomyelitis. Drug Des Devel Ther. 2016 Oct 4;10:3291-3304.
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