GLP-2 (rat) (trifluoroacetate salt) |
| Catalog No.GC90251 |
A gut peptide hormone antagonist of GLP-2R
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Glucagon-like peptide 2 (GLP-2) is a gut peptide hormone antagonist of the GLP-2 receptor (GLP-2R; Ki = 60 pM).1 It increases cAMP levels in COS cells expressing GLP-2R with an EC50 value of 0.58 nM. GLP-2 is primarily produced by enteroendocrine L cells of the small and large intestine but can also be found in the pothalamus.1,2 In vivo, GLP-2 (43.75 μg twice per day for 10 days) increases small bowel weight by 50% and increases villus height and crypt cell proliferation in the small intestine in mice.3 GLP-2 (10 μg per animal) reduces two-hour food intake in rats by 37% with no reduction in water intake.2 Secretion of GLP-2 in rats is stimulated by dietary carbodrates, glucose, dextrin, and oils rich in polyunsaturated or monounsaturated fatty acids.4
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