Glucocorticoid Resistance Inhibitor |
| Catalog No.GC40049 |
Glucocorticoid resistance inhibitor is an inhibitor of glucocorticoid resistance.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 947018-15-7
Sample solution is provided at 25 µL, 10mM.
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Glucocorticoid resistance inhibitor is an inhibitor of glucocorticoid resistance. It inhibits cell growth of the T cell acute lymphoblastic leukemia (T-ALL) cell line CUTTL1 when used in combination with dexamethasone (EC50 = 28 µM) and is less effective when used alone (EC50 = 294 µM). Glucocorticoid resistance inhibitor (6.25-50 µM) preferentially inhibits growth of CUTTL1 cells expressing high levels of the glucocorticoid receptor over cells expressing low levels. It upregulates the gene expression and protein levels of the glucocorticoid receptor and induces expression of dexamethasone-regulated genes when used in combination with dexamethasone but not when used alone.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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