GSK1795091 |
| Catalog No.GC70330 |
GSK1795091 (CRX-601), an immunologic stimulator, is a synthetic TLR4 agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1233589-81-5
Sample solution is provided at 25 µL, 10mM.
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GSK1795091 (CRX-601) ( 0.1 μg /mouse, intranasal administration) as an adjuvant combined with detergent split-influenza antigen (H3N2) induces strong both mucosal and systemic immune responses in mice[2].
GSK1795091 (25 μg/mouse; iv; once weekly for 3 doses) inhibits tumor growth and results in long term survival in tumor model in mice[3].
References:
[1]. Hug BA, et al. Safety, Pharmacokinetics, and Pharmacodynamics of the TLR4 Agonist GSK1795091 in Healthy Individuals: Results from a Randomized, Double-blind, Placebo-controlled, Ascending Dose Study. Clin Ther. 2020;42(8):1519-1534.e33.
[2]. Maroof A, et.al. Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection. PLoS Pathog. 2014 Jan;10(1):e1003875.
[3]. Cebada J, et al. OX40 agonists for cancer treatment: a patent review. Expert Opin Ther Pat. 2021 Jan;31(1):81-90.
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