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DHODH-IN-9

Catalog No.GC70740

DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor.

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DHODH-IN-9 Chemical Structure

Cas No.: 1644156-41-1

Size Price Stock Qty
1mg
$198.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4.

DHODH-IN-9 (Compound 10k) is a corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. With few variations, the pattern of antiviral effect for analogues featuring a 5-cyclopylpyridine is somehow mirroring the one seen for the 5-ethylpyrimidyl bearing homologues. DHODH-IN-9 (Compound 10k) is a good antiviral of this group of analogue[1].

References:
[1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.

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