I-138 |
| Catalog No.GC69249 |
I-138 is an orally effective compound structurally related to ML323. I-138 and ML323 are potent USP1-UAF1 reversible inhibitors. I-138 displays synergistic binding with ubiquitin and mutually exclusive binding with ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increasing mono-ubiquitination of PCNA and FANCD2 in HAP-1 USP1 WT cells. I-138 eliminates self-cleavage of USP1 in cells.
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Cas No.: 2098211-50-6
Sample solution is provided at 25 µL, 10mM.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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