JHU 37160 |
Catalog No.GC50682 |
JHU 37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5nM and 0.2nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively.
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Cas No.: 2369979-68-8
Sample solution is provided at 25 µL, 10mM.
High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in vitro, respectively). Displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21 . Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. Brain penetrant in mice, rats and non-human primates.
Average Rating: 5
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