1-Deoxysphingosine (m18:1(14Z)) (Synonyms: 1-deoxySO, 14Z-1-Deoxysphingosine (d18:1)) |
カタログ番号GC41544 |
1-デオキシスフィンゴシン(m18:1(14Z))は、n-4(14Z)のネイティブ位置に二重結合を含む非典型的なスフィンゴリピドであり、セリンパルミトイルトランスフェラーゼがスフィンゴリピド合成中にセリンの代わりにアラニンとパルミトイルCoAを縮合する際に形成されます。
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Cas No.: 2190487-94-4
Sample solution is provided at 25 µL, 10mM.
1-Deoxysphingosine (m18:1(14Z)) is an atypical sphingolipid that contains a double bond at the n-4 (14Z) native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis. It lacks the C1-hydroxyl group necessary for canonical degradation, however, it is metabolized by the cytochrome P450 (CYP) subfamilies CYP4A and CYP4F in MEF cells.
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