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12-Deoxywithastramonolide (Synonyms: Baimantuoluoside C aglycone, 27-Hydroxywithanolide B)

カタログ番号GC18531

12-デオキシウィタストラモノリドは、アシュワガンダ (W.

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12-Deoxywithastramonolide 化学構造

Cas No.: 60124-17-6

サイズ 価格 在庫数 個数
1mg
$81.00
在庫あり
5mg
$243.00
在庫あり
10mg
$351.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of 12-Deoxywithastramonolide

12-Deoxywithastramonolide is a withanolide found in W. somnifera roots. It has anti-inflammatory activity, reducing Tnf-α and increasing Il-10 production in mice following oral administration at doses ranging from 50-200 mg/kg. 12-Deoxywithastramonolide also reduces the growth of A549 lung and HT-29 colorectal cancer cells (IC50s = 47.1 and 29.8 μM, respectively).

Chemical Properties of 12-Deoxywithastramonolide

Cas No. 60124-17-6 SDF
同義語 Baimantuoluoside C aglycone, 27-Hydroxywithanolide B
Chemical Name 6α,7α-epoxy-5α,22R,27-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone
Canonical SMILES CC(C1)=C(CO)C(O[C@@]1([H])[C@@H](C)[C@@]2([H])CC[C@@]3([H])[C@]4([H])[C@H]5[C@H](O5)[C@@]([C@@]6(C)[C@@]4([H])CC[C@@]32C)(O)CC=CC6=O)=O
Formula C28H38O6 M.Wt 470.6
溶解度 DMF: 2 mg/ml,DMSO: 0.1 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml Storage Store at -20°C,protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 12-Deoxywithastramonolide

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1 mg 5 mg 10 mg
1 mM 2.1249 mL 10.6247 mL 21.2495 mL
5 mM 0.425 mL 2.1249 mL 4.2499 mL
10 mM 0.2125 mL 1.0625 mL 2.1249 mL
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In vivo Formulation Calculator (Clear solution) of 12-Deoxywithastramonolide

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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