(±)-CP 47,497-C8-homolog-d7 (exempt preparation) (Synonyms: Cannabicyclohexanold7)

(±)-CP 47,497-C8-homolog-d₇ (exempt preparation) contains seven deuterium atoms at the 6, 6', 7, 7', 8, 8, and 8 positions. It is intended for use as an internal standard for the quantification of (±)-CP 47,497-C8-homolog (exempt preparation) by GC- or LC-mass spectrometry (MS). (±)-CP 47,497-C8-homolog is a bicyclic cannabinoid (CB) analog that avidly binds the CB₁ receptor (K_i = 0.83 nM) and shows high antinociceptive activity.¹ It is ten-fold more potent than δ⁹-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant, and hypothermic effects in mice.²

1.Melvin, L.S., Milne, G.M., Johnson, M.R., et al.Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: Studies of bicyclic cannabinoid analogsMol. Pharmacol.44(5)1008-1015(1993) 2.Compton, D.R., Johnson, M.R., Melvin, L.S., et al.Pharmacological profile of a series of bicyclic cannabinoid analogs: Classification as cannabimimetic agentsJ. Pharmacol. Exp. Ther.260(1)201-209(1992)