2,3-dinor-8-iso Prostaglandin F1α |
| カタログ番号GC90081 |
アラキドン酸と8-iso PGF2αの活性代謝物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 221664-04-6
Sample solution is provided at 25 µL, 10mM.
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DMSO 2,3-dinor-8-iso Prostaglandin F1α (2,3-dinor-8-iso PGF1α) is an isoprostane and active metabolite of arachidonic acid and the platelet aggregation inhibitor 8-iso PGF2α .1,2 It is formed by the non-enzymatic, free radical peroxidation of arachidonic acid.1 2,3-dinor-8-iso PGF1α induces vasoconstriction in isolated porcine retinal and brain microvessels (EC50s = 12.8 and 18.5 nM, respectively) but does not induce contraction of isolated rat aortic rings when used at a concentration of 31 µM.1,3 It increases thromboxane B2 levels in isolated porcine brain slices when used at a concentration of 1 µM, an effect that can be reversed by the thromboxane A synthase inhibitor CGS 12970, the voltage-gated calcium channel inhibitor SKF 96365 , or nicotinic acetylcholine receptor (nAChR) antagonist α-conotoxin.1
| Cas No. | 221664-04-6 | SDF | |
| Formula | C18H32O5 | M.Wt | 328.4 |
| 溶解度 | DMF: >50 mg/ml (from PGF1.alpha.),DMSO: >50 mg/ml (from PGF1.alpha.),Ethanol: >75 mg/ml (from PGF1.alpha.),PBS pH 7.2: >2 mg/ml (from PGF1.alpha.) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0451 mL | 15.2253 mL | 30.4507 mL |
| 5 mM | 0.609 mL | 3.0451 mL | 6.0901 mL |
| 10 mM | 0.3045 mL | 1.5225 mL | 3.0451 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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