2',3'-Dideoxycytidine-5'-O-triphosphate (sodium salt) |
| カタログ番号GC90804 |
ザルシタビンの活性代謝物
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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2',3'-Dideoxycytidine-5'-O-triphosphate is an active metabolite of the reverse transcriptase inhibitor zalcitabine .1 It is an inhibitor of DNA polymerases β and γ (Kis = 1.32 and 0.034 µM, respectively, for the human enzymes).2 2',3'-Dideoxycytidine-5'-O-triphosphate (1 mM) inhibits HIV-1 replication in isolated human erythrocytes.3 Intraperitoneal administration of 2',3'-dideoxycytidine-5'-O-triphosphate-loaded erythrocytes reduces spleen and lymph node weight, limits increases in IgG levels, and decreases mediastinal lymph node swelling in a mouse model of LP-BM5 leukemic retrovirus infection-induced immunodeficiency.3
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