25G-NBOMe (hydrochloride)

A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects including potent activation of serotonin receptors and many are scheduled as illegal substances. [1][2] 25G-NBOMe (hydrochloride) is a derivative of 2C-G, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine. [3] While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the 5-HT2A serotonin receptor.[4][5]  This product is intended for research and forensic applications.

Reference:
[1]. Moya, P.R., Berg, K.A., Gutiérrez-Hernandez, M.A., et al. Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. Journal of Pharmacology and Experimental Therapeutics 321, 1054-1061 (2007).
[2]. Meyer, M.R., and Maurer, H.H. Metabolism of designer drugs of abuse: An updated review. Curr. Drug Metab. 11(5), 468-482 (2010).
[3]. Zuba, D., and Sekula, K. Analytical characterization of three hallucinogenic N-(2-methoxy)benzyl derivatives of the 2C-series of phenethylamine drugs. Drug Test.Anal. (2012).
[4]. Braden, M.R., Parrish, J.C., Naylor, J.C., et al. Molecular interaction of serotonin 5-HT2A receptor residues Phe3396.51 and Phe3406.52 with superpotent N-benzyl phenethylamine agonists. Mol. Pharm. 70(6), 1956-1965 (2006).
[5]. Ettrup, A., Palner, M., Gillings, N., et al. Radiosysnthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET. J.Nuclear Med. 51(11), 1763-1770 (2010).